PSYCHE, Pure Shift Yielded by Chirp Excitation, is a new method for Pure Shift NMR Spectroscopy which suppresses the effects of homonuclear coupling, allowing 1H spectra to be produced that contain chemical shift only, with no multiplet structure. PSYCHE has superior sensitivity, spectral purity, and tolerance of strong coupling compared to other pure shift techniques. Here PSYCHE is applied to the TOCSY experiment. In combination with covariance processing, the result is a high-quality, high-resolution TOCSY spectrum with singlets in both dimensions: a pure chemical shift correlation map. Such spectra should greatly simplify both manual spectral analysis and automated structure elucidation.


Varian / Agilent
Not Available

Pulse sequence:
f1-psyche-tocsyzqs (right click and chose 'save ... as')

Instructions can be found in the Supplementary Information.

Example Data:
zip file.

Pulse Sequence Diagram:

Foroozandeh M, Adams RW, Meharry NJ, Jeannerat D, Nilsson M, Morris GA. 2014. Ultrahigh-Resolution NMR Spectroscopy Angew. Chem., Int. Ed. In Press and Foroozandeh M, Adams RW, Nilsson M, Morris GA, 2014. Ultrahigh-resolution Total Correlation NMR Spectroscopy J. Am. Chem. Soc. 2014, 136 (34), pp 11867-11869

Please note that copyright restrictions prevent us from placing the pdf files on our website, however, these articles are open access and the pdfs can be downloaded from Wiley and ACS.