GEMSTONE, Gradient-Enhanced Multiplet-Selective Targeted-Observation NMR Experiment, is a method for selecting one signal from a group of overlapping mulitplet signals. GEMSTONE achieves very high selectivity in a single shot by combining chemical shift filtering and spatial multiplexing.


Varian / Agilent
Pulse sequence:
GEMSTONE (right click and chose 'save ... as')

Pulse sequence:
GEMSTONE (right click and chose 'save ... as')
GEMSTONE-NOE (right click and chose 'save ... as')
GEMSTONE-TOCSY (right click and chose 'save ... as')

Example GEMSTONE and GEMSTONE-NOE data can be downloaded from this repository and GEMSTONE-TOSCY data can be downloaded from this repository.

Pulse Sequence Diagram:

Needles from haystacks: single‐scan selective excitation of individual NMR signals in overlapping multiplets
Kiraly P, Kern N, Plesniak MP, Nilsson M,Procter DJ, Morris GM, Adams RW.
Angew. Chem., Int. Ed. 2021, 60, 666-669.

Please note that copyright restrictions prevent us from placing the pdf files on our website, however, the article is open access and can be downloaded from Wiley.

Single-scan ultra-selective 1D total correlation spectroscopy
Kiraly P, Nilsson M, Morris GM, Adams RW.
Chem. Commun. 2021, In Press (DOI: 10.1039/D0CC08033K).