Summary:
Selective 1D COSY can unambiguously identify coupled spins but is often limited both by lack of selectivity, and by unfavourable multiplet lineshapes. Here, ultra selective GEMSTONE excitation is employed with CLIP-COSY to provide through-bond correlations for nuclei whose NMR signals overlap.
Downloads:
Bruker pulse sequences:
GEMSTONE-COSY (Bruker DRX, Topspin 1.x) (right click and chose 'save ... as')
GEMSTONE-COSY (Bruker Avance II+, Topspin 3.x) (right click and chose 'save ... as')
GEMSTONE CLIP-COSY (Bruker DRX, Topspin 1.x) (right click and chose 'save ... as')
GEMSTONE CLIP-COSY (Bruker Avance II+, Topspin 3.x) (right click and chose 'save ... as')
JEOL pulse sequences:
GEMSTONE-COSY (JEOL ECZ/ECZL, Delta 6.x) (right click and chose 'save ... as')
GEMSTONE CLIP-COSY (JEOL ECZ/ECZL, Delta 6.x) (right click and chose 'save ... as')
Example data:
GEMSTONE CLIP-COSY repository
Pulse Sequence Diagrams:
References:
Ultra-selective 1D clean in-phase correlation spectroscopy
Taylor DA, Kiraly P, Bowyer P, Nilsson M, Castanar L, Morris GA, Adams RW.
Chem. Commun. 2023, Accepted Manuscript (DOI: 10.1039/D3CC01333B).
GEMSTONE-TOCSY: Single-scan ultra-selective 1D total correlation spectroscopy
Kiraly P, Nilsson M, Morris GM, Adams RW.
Chem. Commun., 2021, 57, 2368-2371.
GEMSTONE: Needles from haystacks: single‐scan selective excitation of individual NMR signals in overlapping multiplets
Kiraly P, Kern N, Plesniak MP, Nilsson M,Procter DJ, Morris GM, Adams RW.
Angew. Chem. Int. Ed., 2021, 60, 666-669.
Please note that copyright restrictions prevent us from placing the pdf files on our website, however, all articles are published open access and can be downloaded from the respective publishers.