Selective 1D TOCSY is a powerful tool in the assignment of NMR spectra of organic molecules. Here an order of magnitude improvement in selectivity, allowing overlapping multiplets to be excited separately, is achieved in a single scan using the very recent GEMSTONE method.

Bruker pulse sequences:
GEMSTONE-TOCSY (right click and chose 'save ... as')

JEOL pulse sequences:
GEMSTONE-TOCSY (JEOL ECZ/ECZL, Delta 6.x) (right click and chose 'save ... as')

Example data:

Pulse Sequence Diagrams:


Single-scan ultra-selective 1D total correlation spectroscopy
Kiraly P, Nilsson M, Morris GM, Adams RW.
Chem. Commun., 2021, 57, 2368-2371.

GEMSTONE: Needles from haystacks: single‐scan selective excitation of individual NMR signals in overlapping multiplets
Kiraly P, Kern N, Plesniak MP, Nilsson M,Procter DJ, Morris GM, Adams RW.
Angew. Chem. Int. Ed., 2021, 60, 666-669.

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