Laura Castañar Acedo

Picture of Laura Castañar Acedo

Post-Doctoral Research Associate
Tel: 0161 275 4669
Location: Room 7.07
Chemistry Building
School of Chemistry
The University of Manchester
M13 9PL

Design and development of high-resolution NMR methods
Pure shift NMR spectroscopy
NMR mixute analysis
NMR structure elucidation

I earned my Bachelor of Science in Chemistry at the Complutense University of Madrid (Spain) in 2011. I then moved to Barcelona to carry out my Master studies on Chemical Sciences and Technologies at the Autonomous University of Barcelona (Spain).
In 2012 I started my Ph.D. studies in NMR Spectroscopy at the Autonomous University of Barcelona (Spain) supervised by Dr. Teodor Parella and Dr. Albert Virgili. My PhD research was focused on the design of modern pure shift NMR methodologies and improved HSQC- and HSQMBC-type experiments to measure homo- and heteronuclear scalar and residual dipolar coupling constants.
In Novembre 2015 I moved to Manchester where I am now doing my post-doctoral research at the University of Manchester, supervised by Dr. Mathias Nilsson and Prof. Gareth Morris.

19. The GNAT: a new tool for processing NMR data. L. Castañar, G. Dal Poggetto, A. Colbourne, G. A. Morris, M. Nilsson. Mag. Reson. Chem., 2018. DOI: 10.1002/mrc.4717. GNAT can be downloaded from here.

18. Relaxation-encoded NMR experiments for mixture analysis: REST and beer. G. Dal Poggetto, L. Castañar, R. W. Adams, G. A. Morris, M. Nilsson. Chem. Commun. 2017, 53, 7461-7464. DOI: 10.1039/C7CC03150E

17. Pure shift 1H NMR: what is next? L. Castañar. Mag. Reson. Chem., 2017, 55, 47–53. DOI: 10.1002/mrc.4545

16. Ultrahigh-Resolution Diffusion-Ordered Spectroscopy. M. Foroozandeh, L. Castañar, L. G. Martins, D. Sinnaeve, G. Dal Poggetto, C. F. Tormena, R. W. Adams, G. A. Morris, M. Nilsson.
Angew. Chem. Int. Ed. 2016, 55, 15579-15582. DOI: 10.1002/anie.201609676
Angew. Chem. 2016, 128, 15808-15811. DOI: 10.1002/ange.201609676

15. A new tool for NMR analysis of complex systems: selective pure shift TOCSY. G. Dal Poggetto, L. Castañar, G. A. Morris, M. Nilsson. RSC Adv., 2016, 6, 100063-100066. DOI:10.1039/C6RA22807K

14. One-shot determination of residual dipolar couplings. Application to the structural discrimination of small molecules containing multiple stereocenters; L. Castañar, M. García, E. Hellemann, P. Nolis, R. R. Gil, T. Parella. J. Org. Chem., 2016, 81, 11126-11131. DOI: 10.1021/acs.joc.6b02103

13. L. Castañar, T. Parella. “Broadband 1H homodecoupled NMR Experiments: Recent developments, methods and applications”. Mag. Reson. Chem., 2015, 53, 399-426. DOI: 10.1002/mrc.4238

12 L. Castañar, R. Roldan, P. Clapés, A. Virgili, T. Parella. “Disentangling complex mixtures of compounds with near-identical 1H and 13C NMR spectra using pure shift NMR spectroscopy”. Chem. Eur. J., 2015, 21, 7682-7685. DOI: 10.1002/chem.201500521

11 L. Castañar, T. Parella. “Recent advances in small molecule NMR: improved HSQC and HSQMBC experiments”. Annu. Rep. NMR Spectrosc., 2015, 84, 163-232. DOI: 10.1016/bs.arnmr.2014.10.004

10. L. Castañar, E. Sistaré, A. Virgili, R. T. Williamson, T. Parella, “Suppression of phase and amplitude JHH modulations in HSQC experiments”. Magn. Reson. Chem., 2014, 53, 115-119. DOI:10.1002/mrc.4149

9. M. Pérez-Trujillo, L. Castañar, E. Monteagudo, L. T. Khun, P. Nolis, A. Virgili, R. T. Williamson, T. Parella, “Simultaneous 1H and 13C NMR enantiodifferentiation from highly-resolved pure shift HSQC spectra”. Chem. Comm, 2014, 50, 10214-10217. DOI: 10.1039/C4CC04077E

8. L. Castañar, J. Saurí, R. T. Williamson, A. Virgili, T. Parella, “Pure in-phase heteronuclear correlation NMR experiments”. Angew. Chem. Int. Ed., 2014, 53, 8379-8382. DOI: 10.1002/anie.201404136. Angew. Chem., 2014, 126, 8519-8522. DOI: 10.1002/ange.201404136

7. L. Castañar, P. Nolis, A. Virgili, T. Parella, “Measurement of T1/T2 relaxation times in overlapped regions from homodecoupled 1H singlet signals”. J. Magn. Reson., 2014, 244, 30-35. DOI: 10.1016/j.jmr.2014.04.003

6. L. Castañar, M. Pérez-Trujillo, P. Nolis, E. Monteagudo, A. Virgili, T. Parella, “Enantiodifferentiation through frequency-selective pure shift 1H Nuclear Magnetic Resonance Spectroscopy”. ChemPhysChem, 2014, 15, 854-857. DOI: 10.1002/cphc.201301130

5. J. Saurí, L. Castañar, P. Nolis, A. Virgili, T. Parella, “Straightforward measurement of individual 1JCH and 2JHH in diastereotopic CH2 groups”. J. Magn. Reson., 2014, 242, 33-40. DOI: 10.1016/j.jmr.2014.02.003

4. L. Castañar, J. Saurí, P. Nolis, A. Virgili, T. Parella, “Implementing homo- and heterodecoupling in region-selective HSQMBC experiments”. J. Magn. Reson., 2014, 238, 63-69. DOI: 10.1016/j.jmr.2013.10.022

3. L. Castañar, P. Nolis, A. Virgili, T. Parella, “Full sensitivity and enhanced resolution in homodecoupled band-selective NMR experiments”. Chem. Eur. J., 2013, 19, 17283-17286. DOI: 10.1002/chem.201303235

2. L. Castañar, P. Nolis, A. Virgili, T. Parella, “Simultaneous multi-slice excitation in spatially encoded NMR experiments”. Chem. Eur. J., 2013, 19, 15472-15475. DOI: 10.1002/chem.201303272

1. J. Saurí, L. Castañar, P. Nolis, A. Virgili, T. Parella, “P.E. HSQMBC: Simultaneous measurement of proton-proton and proton-carbon coupling constants”. J. Magn. Reson., 2012, 224, 101-106. DOI: 10.1016/j.jmr.2012.09.007