Difluorinated analogues of shikimic acid

Mon, 03/14/2011 - 12:22 — ralph

Title	Difluorinated analogues of shikimic acid
Publication Type	Journal Article
Year of Publication	2003
Authors	Begum, L, Box JM, Drew MGB, Harwood LM, Humphreys JL, Lowes DJ, Morris GA, Redon PM, Walker FM, Whitehead RC
Journal	Tetrahedron
Volume	59
Pagination	4827-4841
ISBN Number	0040-4020
Accession Number	WOS:000183780900016
Abstract	Investigations into the quinate to shikimate transformation have been carried out, the results of which have been exploited in the synthesis of a novel difluoromethylene homologue of shikimic acid from (-)-quinic acid. Martin's sulfurane {Ph2S[OC(CF3)(2)Ph](2)} was the reagent of choice for the key dehydration step of this synthesis. The results of investigations into the synthesis of the important natural product analogue, 6,6-difluoroshikimic acid are also reported. (C) 2003 Elsevier Science Ltd. All rights reserved.
URL	http://apps.isiknowledge.com/UA_GeneralSearch_input.do?product=UA&search_mode=GeneralSearchWOS:000183780900016

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