@article {202, title = {A diffusion-ordered NMR spectroscopy study of the solubilization of artemisinin by octanoyl-6-O-ascorbic acid micelles}, journal = {Journal of Pharmaceutical Sciences}, volume = {91}, number = {10}, year = {2002}, note = {Times Cited: 18}, pages = {2265-2270}, abstract = {Artemisinin (QHS) is a natural drug with a very low solubility in water. To improve its availability in hydrophilic media, it was solubilized in micellar dispersions of octanoyl-6-O-ascorbic acid (ASC8), a relatively novel surfactant that combines surface activity with powerful performance as radical scavenger. In this article we report a study based on diffusion-ordered NMR spectroscopy (DOSY) measurements carried out on QHS/ASC8 micellar dispersions. QHS is efficiently solubilized by ASC8 micelles, with no significant perturbation of the micellisation. (C) 2002 Wiley-Liss, Inc.}, isbn = {0022-3549}, url = {://WOS:000178107600017}, author = {Bilia, Anna Rita and Bergonzi, M. C. and Vincieri, F. F. and Lo Nostro, P. and Morris, Gareth A.} }